Melagenol, a natural oral nutri-cosmetic formulation offers excellent skin lightening and whitening properties. Produced from plant extracts, it is proven safe and effective as both a beauty aid and in the treatment of skin pigmentation disorders.

Melagenol is designed as a better alternative to skin lightening creams and lotions. When taken orally as a dietary supplement, Melagenol protects the whole body from the appearance of unwanted marks – avoiding discolouration.

Melagenol is a combination of powerful natural extracts from two plants:

Aloysia Tryphilla and Arctostaphylos uva-ursi

They are considered to be safe alternatives to other de-pigmentation agents commonly used to make the skin fairer.
Melagenol prevents the production of melanin – the chemical that causes the skin to darken – by inhibiting tyrosinase, the enzyme that regulates it. 

Melagenol influences the different pathways involved in melanin formation in three main ways:

• Before melanin synthesis, by inhibiting tyrosinase synthesis•
• During melanin synthesis, by directly inhibiting tyrosinase activity•
• Inhibition of the skin’s melanogenic response through direct anti-inflammatory & antioxidant activity

The two main active compounds in Melagenol are verbascoside (>15%) and arbutin (>10%), which work together to inhibit melanin synthesis and maintain a consistent skin tone. These compounds have been carefully selected by the Spanish manufacturer (Monteloedor) for both their individual efficacy and their synergistic effect, as established through different bioassays.

At 50μM, both verbascoside and arbutin show approximately two-fold greater melanininhibition than kojic acid, a plant extract often used in skin lightening products

Verbascoside, which is also sometimes known as acteoside, is a naturally occurring ortho-dihydroxycinnamic acid derived from the plant Aloysia Tryphilla.  It offers a wide range of benefits, including antioxidant, anti-inflammatory, photo-protective and skin whitening actions.


Arbutin, which is derived from the Arctostaphylos uva-ursi plant, is a naturally occurring β-D-glucopyranoside. It is known for preventing melanogenesis through tyrosinase inhibition activity

.
The combination of the Arctostaphylos uva-ursi and Aloysia Tryphilla extracts, and their active compounds, maximises the skin whitening efficacy of Melagenol, and makes it the perfect choice for products designed to lighten the skin and treat melanogenesis

Melagenol works by influencing the different pathways involved in the synthesis of melanin – the chemical that causes the skin to darken. Thanks to its relatively low required dosage (300-500mg daily),

It simply offers highly effective skin-lightening without side effects, which means it is ideal for both general skin whitening and the treatment of unwanted dark patches on the skin. With Melagenol, it is now possible to give you lighter skin from within.

There is strong scientific evidence to support the efficacy of Melagenol. In a recent study performed at the University Miguel Hernandez in Elche, Spain, it was shown to inhibit melanin production in melanocytes, the cells that produce melanin, in a dose-response manner – thus preventing the appearance of unattractive dark spots on the skin.

Melagenol has a ‘triple action’ that
increases the efficacy of its whitening effect, as follows:

Direct inhibition of the main enzyme responsible for producing melanin –
tyrosinase

An antioxidant effect that limits melanin production by reducing oxidative stress
and the activity of the free radicals produced by UV radiation

An anti-inflammatory action that blocks the inflammatory mediators in the skin that have been shown to stimulate melanin synthesis after exposure to UV radiation.
It is also it is highly effective in the prevention or reduction of age-related or photo-induced spots on the skin.

Epifade Skin Lightening Supplement contains Melagenol at 400mg